Bought an extra wheel, sold the steel spare wheel. I do a 5 tire rotation. 25% longer life (time, not miles) from the tires versus leaving it under the bed until I need it.
Running a husqvarna 701 enduro. Loaded straight in, cannot get the bed extender. Might be possible if the bike is angle a bit.
I should mention this is with a roll up tonneau cover taking some space in the front of the bed though.